Akademik Veri Yönetim Sistemi
73 International rd Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA), Naples, İtalya, 31 Ağustos - 03 Eylül 2025, ss.515-516, (Özet Bildiri)
Carvacrol (Car) is a monoterpenic compound found in Oregano species and has numerous biological
activites such as antioxidant effect. However, direct use of the Car molecule is difficult due to its
pungent odor, easy oxidation and irritating structure. Nowadays, loading into polymeric structures in
the nanoparticles is becoming widespread to reduce such as side effects [1].
Our previous study evaluated collagenase inhibitory activity by encapsulating Car into polycaprolactone
(PCL) nanoparticles (NPs). In this study, the antioxidant activity of Car-PCL-NPs obtained
using the same encapsulation system was examined and its effectiveness was evaluated in comparison
with free Car [2]. It was predicted that the antioxidant activity of Car, whose irritating effect and
strong odor were already eliminated by encapsulation, would also increase in this form.
In the study, ABTS, DPPH, CUPRAC and metal chelating antioxidant tests were performed on free
Car and Car-PCL-NPs. As a result, free Car showed antioxidant effect in all of them, but it was observed
that Car-PCL-NPs were active only in ABTS and CUPRAC tests. This activity is approximately
10 times higher in the ABTS test and 8 times higher in the CUPRAC test compared to free Car.
According to the results, it was determined that the activity of the Car loaded into NPs increased
significantly. Also, volatility and irritating properties were eliminated, making Car easier to use. Thus,
it was predicted that Car-PCL-NPs could be suitable candidates for use in the cosmetic industry as
more stable and bioavailable active structures for anti-aging, skin brightening topical formulations.