Preconditioning effects of on myocardial ischemia/reperfusion injury in rats

Kocoglu H., Karaaslan K., Gonca E., Bozdogan O., Gulcu N.

CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL, cilt.69, sa.2, ss.150-158, 2008 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 69 Sayı: 2
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1016/j.curtheres.2008.04.003
  • Dergi Adı: CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.150-158
  • Anahtar Kelimeler: dexmedetomidine, preconditioning, cardiac ischemia/reperfusion, ANESTHETIZED DOGS, ISCHEMIC MYOCARDIUM, DEXMEDETOMIDINE, REPERFUSION, ARRHYTHMIAS, INFARCTION, SURGERY, MODEL
  • Bezmiâlem Vakıf Üniversitesi Adresli: Hayır

Özet

BACKGROUND: Preconditioning might protect the myocardium against ischemia/reperfusion injury by reducing infarct size and preventing arrhythmias. Dexmedetomidine (DEX) is a highly selective alpha(2)-agonist used for sedoanalgesia in daily anesthetic practice. The cardioprotective effects of DEX on infarct size and on the incidence of arrhythmias observed after regional ischemia/reperfusion injury in vivo have not been reported.