Preconditioning effects of on myocardial ischemia/reperfusion injury in rats

Kocoglu H., Karaaslan K. , Gonca E., Bozdogan O., Gulcu N.

CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL, vol.69, no.2, pp.150-158, 2008 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 69 Issue: 2
  • Publication Date: 2008
  • Doi Number: 10.1016/j.curtheres.2008.04.003
  • Title of Journal : CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL
  • Page Numbers: pp.150-158
  • Keywords: dexmedetomidine, preconditioning, cardiac ischemia/reperfusion, ANESTHETIZED DOGS, ISCHEMIC MYOCARDIUM, DEXMEDETOMIDINE, REPERFUSION, ARRHYTHMIAS, INFARCTION, SURGERY, MODEL

Abstract

BACKGROUND: Preconditioning might protect the myocardium against ischemia/reperfusion injury by reducing infarct size and preventing arrhythmias. Dexmedetomidine (DEX) is a highly selective alpha(2)-agonist used for sedoanalgesia in daily anesthetic practice. The cardioprotective effects of DEX on infarct size and on the incidence of arrhythmias observed after regional ischemia/reperfusion injury in vivo have not been reported.