Preconditioning effects of on myocardial ischemia/reperfusion injury in rats


Kocoglu H., Karaaslan K. , Gonca E., Bozdogan O., Gulcu N.

CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL, cilt.69, ss.150-158, 2008 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 69 Konu: 2
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1016/j.curtheres.2008.04.003
  • Dergi Adı: CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL
  • Sayfa Sayısı: ss.150-158

Özet

BACKGROUND: Preconditioning might protect the myocardium against ischemia/reperfusion injury by reducing infarct size and preventing arrhythmias. Dexmedetomidine (DEX) is a highly selective alpha(2)-agonist used for sedoanalgesia in daily anesthetic practice. The cardioprotective effects of DEX on infarct size and on the incidence of arrhythmias observed after regional ischemia/reperfusion injury in vivo have not been reported.