Determinants of mortality among elderly subjects with chronic kidney disease

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Heybeli C., SOYSAL P., KAZANCIOĞLU R.

Turkish Journal of Nephrology, vol.30, no.3, pp.193-198, 2021 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 3
  • Publication Date: 2021
  • Doi Number: 10.5152/turkjnephrol.2021.4657
  • Journal Name: Turkish Journal of Nephrology
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.193-198
  • Keywords: Aged, mortality, chronic renal insufficiency, SERUM URIC-ACID, CARDIOVASCULAR EVENTS, DEATH, RISK, OUTCOMES, HEALTH, CKD
  • Bezmialem Vakıf University Affiliated: Yes

Abstract

© 2021 Turkish Society of Nephrology. All rights reserved.Objective: Studies on predictors of mortality among elderly chronic kidney disease (CKD) patients have conflicting results. We aimed to assess the factors related to mortality in CKD versus non-CKD elderly subjects. Methods: Medical records of consecutive elderly subjects presented to geriatrics outpatient clinics were retrospectively searched. Logistic regression models were set in order to determine independent predictors of mortality. Results: The median age was 73 (67-80) years, and 837 (67.9%) were female. CKD constituted 21.9% of the cohort. During the follow-up of 3 to 4 years, 7.2% of the patients died. In the CKD cohort, older age (per year, OR 1.12, 95% CI 1.01-1.25, P = .040) and serum uric acid levels (per 1 mg/dL increase, OR 1.74, 95% CI 1.12-2.69, P = .013) were associated with a higher risk of mortality while serum albumin (per 1 g/dL increase, OR 0.08, 95% CI 0.01-0.52, P = .008) and vitamin D levels (per 1 ng/mL increase, OR 0.77, 95% CI 0.62-0.96, P = .019) were associated with a lower risk of mortality in the multivariate regression model. Conclusion: Older age, lower serum albumin and vitamin D levels, and higher serum uric acid levels are independent predictors of mortality in outpatient elderly subjects with CKD.