Synthesis, characterization of some transition-metal complexes of a new heptadentate N(5)S(2) Schiff-base ligand and the effects of these metal complexes on U2OS cells cytotoxicity and DNA cleavage activity


Ulucam G., Beynek N., Seller Z., Akalin G., Turan G., Benkli K.

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, cilt.183, ss.2237-2247, 2008 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 183 Konu: 9
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1080/10426500801907589
  • Dergi Adı: PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
  • Sayfa Sayısı: ss.2237-2247

Özet

Metal complexes of a heptadentate N(5)S(2) donor Schiff-base ligand were synthesized by the template reaction between 2,6-bis(2-aminothiophenoxymethyl)pyridine and 2,2 '-bipyridine-6,6'-dicarboxaldehyde in the presence of Zn(II), Cd(II), Hg(II) and Pb(II) perchlorate salts. The complexes were characterized by IR, 1H NMR, MS-FAB+, and elemental analyses. The mitochondrial activity of U2OS cells after exposure to these complexes was determined by colorimetric assay, which detects the conversion of 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide (MTT) to formazon. DNA-binding activity of all complexes was also investigated using plasmid DNA pUC18 purified from E. coli.