Relationship between levels of DNA damage in lymphocytes and histopathological severity of chronic hepatitis C and various clinical forms of hepatitis B

BOLUKBAS C., BOLUKBAS F., Kocyigit A., ASLAN M., SELEK S., BITIREN M., ...More

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, vol.21, no.3, pp.610-616, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 3
  • Publication Date: 2006
  • Doi Number: 10.1111/j.1440-1746.2005.04069.x
  • Journal Name: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.610-616
  • Keywords: cirrhosis, comet assay, DNA damage, hepatitis B, hepatitis C, inactive hepatitis B s antigen (HBsAg) carrier, PERIPHERAL-BLOOD LYMPHOCYTES, HEPATOCELLULAR-CARCINOMA, COMET ASSAY, INTERFERON THERAPY, OXIDATIVE STRESS, REACTIVE OXYGEN, NITRIC-OXIDE, CANCER, HEPATOCARCINOGENESIS, LEUKOCYTES
  • Bezmialem Vakıf University Affiliated: No

Abstract

Background and Aim: A significant proportion of cancer is attributable to DNA damage caused by chronic infection and inflammation. Because both hepatitis B and C viruses (HBV and HCV, respectively) cause chronic infection and inflammatory disease, the aim of the present study was to investigate whether there is a difference in peripheral DNA damage in patients with chronic HCV compared with patients with chronic HBV; and whether there is an association in the level of peripheral DNA damage with a natural history of HBV infection.