Relationship between levels of DNA damage in lymphocytes and histopathological severity of chronic hepatitis C and various clinical forms of hepatitis B


BOLUKBAS C., BOLUKBAS F., Kocyigit A. , ASLAN M., SELEK S. , BITIREN M., ...More

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, vol.21, no.3, pp.610-616, 2006 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 3
  • Publication Date: 2006
  • Doi Number: 10.1111/j.1440-1746.2005.04069.x
  • Title of Journal : JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
  • Page Numbers: pp.610-616

Abstract

Background and Aim: A significant proportion of cancer is attributable to DNA damage caused by chronic infection and inflammation. Because both hepatitis B and C viruses (HBV and HCV, respectively) cause chronic infection and inflammatory disease, the aim of the present study was to investigate whether there is a difference in peripheral DNA damage in patients with chronic HCV compared with patients with chronic HBV; and whether there is an association in the level of peripheral DNA damage with a natural history of HBV infection.