Relationship between levels of DNA damage in lymphocytes and histopathological severity of chronic hepatitis C and various clinical forms of hepatitis B

BOLUKBAS C., BOLUKBAS F., Kocyigit A., ASLAN M., SELEK S., BITIREN M., ...Daha Fazla

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, cilt.21, sa.3, ss.610-616, 2006 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 3
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1111/j.1440-1746.2005.04069.x
  • Dergi Adı: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.610-616
  • Anahtar Kelimeler: cirrhosis, comet assay, DNA damage, hepatitis B, hepatitis C, inactive hepatitis B s antigen (HBsAg) carrier, PERIPHERAL-BLOOD LYMPHOCYTES, HEPATOCELLULAR-CARCINOMA, COMET ASSAY, INTERFERON THERAPY, OXIDATIVE STRESS, REACTIVE OXYGEN, NITRIC-OXIDE, CANCER, HEPATOCARCINOGENESIS, LEUKOCYTES
  • Bezmiâlem Vakıf Üniversitesi Adresli: Hayır

Özet

Background and Aim: A significant proportion of cancer is attributable to DNA damage caused by chronic infection and inflammation. Because both hepatitis B and C viruses (HBV and HCV, respectively) cause chronic infection and inflammatory disease, the aim of the present study was to investigate whether there is a difference in peripheral DNA damage in patients with chronic HCV compared with patients with chronic HBV; and whether there is an association in the level of peripheral DNA damage with a natural history of HBV infection.