Classification of Dengue Fever Patients Based on Gene Expression Data Using Support Vector Machines

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Gomes A. L. V., Wee L. J. K., KHAN M. A., Gil L. H. V. G., Marques E. T. A., Calzavara-Silva C. E., ...More

PLOS ONE, vol.5, no.6, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 5 Issue: 6
  • Publication Date: 2010
  • Doi Number: 10.1371/journal.pone.0011267
  • Journal Name: PLOS ONE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Bezmialem Vakıf University Affiliated: Yes

Abstract

Background: Symptomatic infection by dengue virus (DENV) can range from dengue fever (DF) to dengue haemorrhagic fever (DHF), however, the determinants of DF or DHF progression are not completely understood. It is hypothesised that host innate immune response factors are involved in modulating the disease outcome and the expression levels of genes involved in this response could be used as early prognostic markers for disease severity.