Increased oxidant status in children with breath-holding spells


Calik M., Abuhandan M., Aycicek A., Taskin A., Selek S. , Iscan A.

CHILDS NERVOUS SYSTEM, vol.29, no.6, pp.1015-1019, 2013 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 6
  • Publication Date: 2013
  • Doi Number: 10.1007/s00381-012-2001-8
  • Title of Journal : CHILDS NERVOUS SYSTEM
  • Page Numbers: pp.1015-1019
  • Keywords: Antioxidants, Breath-holding spells, Infants, Iron-deficiency anemia, Oxidative stress, IRON-DEFICIENCY ANEMIA, OXIDATIVE STRESS, GLUTATHIONE-PEROXIDASE, SUPEROXIDE-DISMUTASE, ANTIOXIDANT STATUS, NERVOUS-SYSTEM, SUSCEPTIBILITY, CELLS

Abstract

Breath-holding spells (BHS) are the most common form of non-epileptic paroxysmal events in infancy. The pathophysiology of BHS is not fully understood. Iron-deficiency anemia (IDA) may be a factor contributing to breath-holding spells. Although numerous reports have shown that elevated oxidative stress is implicated in the pathophysiology of neurodegenerative diseases and neurological conditions, such as epileptic seizures, brain damage, and neurotrauma, there are no data regarding the role of oxidative stress in the development of BHS. This study aimed to investigate oxidative stress in children with BHS.