Plasma total thiol pool in children with asthma: Modulation during montelukast monotherapy

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DILEK F., Ozkaya E., Kocyigit A., Yazici M., Guler E. M., DUNDAROZ M. R.

INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY, vol.29, no.1, pp.84-89, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 1
  • Publication Date: 2016
  • Doi Number: 10.1177/0394632015621563
  • Journal Name: INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.84-89
  • Keywords: asthma, children, montelukast, plasma, TAS, thiol, treatment, OXIDATIVE STRESS, PARAMETERS, ANTAGONIST, PROTEIN, DAMAGE, LUNG
  • Bezmialem Vakıf University Affiliated: Yes

Abstract

Background: Inflammation, which is a hallmark of asthma, is one of the main sources of oxidative stress in the human body. Thiols are powerful antioxidants that protect cells against the consequences of oxidative stress. We aimed to investigate whether asthma and montelukast monotherapy affect the total plasma thiol pool in children.