Objective: The aim of this study was to assess the histopathological effect of resveratrol in thyroid tissue of rats exposed to cigarette smoke. Material and Methods: Forty adult, male Wistar Albino rats were divided into four groups for an experiment of 6 weeks duration. Group I was the control group. Rats in group 2 were exposed to cigarette smoke only and rats in group 3 received daily intraperitoneal injections of resveratrol (10 mg/kg/d). Animals in group 4 were exposed to both cigarette smoke and intraperitoneal injections of resveratrol. Rats of all groups were sacrificed; their thyroid glands were removed and were examined histopathologically. Results: While the control group and the resveratrol group had normal thyroid tissue, in the group exposed to cigarette smoke there was a significant decrease in follicles and differentiation of epithelial cells from cubic to flat cells. There was intracytoplasmic vacuolization in some epithelial cells, irregularity in follicular cells decreasing area and cell infiltrations. On the other hand, we observed significant improvement in these histopathological differences in the group that was exposed to both cigarette smoke and resveratrol. Conclusion: Resveratrol has healing effects on the damage of thyroid tissue of rats that are exposed to cigarette smoke at a dose and duration tested in this study.