The effects of carbon tetrachloride (CCl4) induced experimental acute and chronic intoxication on histological structure of liver and some hematological values and electrocardiogram in rabbits


Cınar A., Yoruk M., Meral I. , Kılıcalp D., Koc A., Ertekın A.

TURKISH JOURNAL OF VETERINARY & ANIMAL SCIENCES, vol.23, pp.235-242, 1999 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 23
  • Publication Date: 1999
  • Title of Journal : TURKISH JOURNAL OF VETERINARY & ANIMAL SCIENCES
  • Page Numbers: pp.235-242

Abstract

This paper reports an investigation of the effects of acute and chronic carbon tetrachloride intoxications on the histologic structure of the liver and hematological values and electrocardiograms in rabbits. The rabbits were divided into 3 groups of 7. The first group was the control group, the second group was acutely intoxicated and the third group was chronically intoxicated. In the acutely intoxicated group, caryorexsis, along with necrosis was observed in the hepatocyte of the centrolobular area of the liver. In the chronically intoxicated group, connective tissue mass around the V. centralis increased. This increase of connective tissue caused chirrosis. Hematological values of the groups were as follows: red blood cells 5.86+/-0.6, 5.95+/-1.5, 4.26+/-0.7 billion/mm(3); white blood cell: 6.9+/-1.35, 5.90+/-0.8, 4.0+/-2.44 thousand/mm(3); hemoglobin concentration: 12.7+/-0.9, 13.6+/-1.5, 11.8+/-1.2 gr/dl; hematocrit value: 41.8+/-3.3, 44.6+/-4.9, 33.0+/-4.4%; sedimentation: 5.2+/-1.6, 8.0+/-2.8, 10.2+/-1.3 45 degrees/1 hours respectively. The formula leukocyte was as follows: in the control group: neutrophil 34+/-5.3%, eosinophil 0.6+/-0.8%, basophil 0.2+/-0.4%, lymphocyte 62+/-5.02%, monocyte 3.2+/-0.97%. In the acutely intoxicated group: neutrophil 7.75+/-1.1%; eosinophil 1+/-0%; basophil 0+/-0%; lymphocyte 88.5+/-1.3%; monocyte 3.5+/-1.8%. In the chronically intoxicated group: neutrophil 60+/-8.51%; eosinophil 1+/-0.71%; basophil 0+0%: lymphocyte 35.75+/-7.33%; monocyte 3.2+/-0.83%.