Immunoexpression of TTF-1 in Non-Lung Tumors

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TOSUNER Z., ARICI D. S., GÜCİN Z., BÜYÜKPINARBAŞILI N., SÖNMEZ F. C., YILDIZ P.

BEZMIALEM SCIENCE, vol.2, no.4, pp.95-97, 2014 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 2 Issue: 4
  • Publication Date: 2014
  • Doi Number: 10.14235/bs.2014.336
  • Journal Name: BEZMIALEM SCIENCE
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.95-97
  • Bezmialem Vakıf University Affiliated: Yes

Abstract

Objective: Thyroid transcription factor-1 (TTF-1) immunoexpression is frequently determined in small-cell lung carcinomas, as well as primary lung adenocarcinomas. While dealing with metastatic carcinomas, TTF-1 immunoexpression is a significant indicator of primary lung carcinomas. Recent studies have revealed that TTF-1 immunoexpression is also defined in non-lung cancers, such as squamous cell carcinomas of different sites and certain neuroendocrine tumors. The verified data obtained from these studies indicate that a straightforward diagnosis of primary lung carcinoma in cases with positive TTF-1 immunoexpression can cause diagnostic contradictions. The aim of our study is to investigate the immunoexpression status of TTF-1 in common non-lung tumors.