Immunoexpression of TTF-1 in Non-Lung Tumors


TOSUNER Z. , ARICI D. S. , GÜCİN Z. , BÜYÜKPINARBAŞILI N. , SÖNMEZ F. C. , YILDIZ P.

BEZMIALEM SCIENCE, vol.2, no.4, pp.95-97, 2014 (Journal Indexed in ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 2 Issue: 4
  • Publication Date: 2014
  • Doi Number: 10.14235/bs.2014.336
  • Title of Journal : BEZMIALEM SCIENCE
  • Page Numbers: pp.95-97

Abstract

Objective: Thyroid transcription factor-1 (TTF-1) immunoexpression is frequently determined in small-cell lung carcinomas, as well as primary lung adenocarcinomas. While dealing with metastatic carcinomas, TTF-1 immunoexpression is a significant indicator of primary lung carcinomas. Recent studies have revealed that TTF-1 immunoexpression is also defined in non-lung cancers, such as squamous cell carcinomas of different sites and certain neuroendocrine tumors. The verified data obtained from these studies indicate that a straightforward diagnosis of primary lung carcinoma in cases with positive TTF-1 immunoexpression can cause diagnostic contradictions. The aim of our study is to investigate the immunoexpression status of TTF-1 in common non-lung tumors.