A new antibacterial diterpene from the roots of Salvia caespitosa

ULUBELEN A., OKSUZ S., Topcu G., GOREN A. C., BOZOK-JOHANSSON C., CELIK C., ...More

NATURAL PRODUCT LETTERS, vol.15, no.5, pp.307-314, 2001 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 5
  • Publication Date: 2001
  • Doi Number: 10.1080/10575630108041297
  • Journal Name: NATURAL PRODUCT LETTERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.307-314
  • Keywords: Salvia caespitosa, lamiaceae, terpenoids, 6 beta-hydroxyisopimaric acid, 3-acetylvergatic acid, antibacterial activity, ABIETANE DITERPENOIDS, PINNATA
  • Bezmialem Vakıf University Affiliated: No

Abstract

From the roots of Saliva caespitosa Montbret and Aucher ex. Bentham a new diterpene 6beta-hydroxyisopimaric acid (1) has been isolated together with four known diterpenes, one new triterpenoid, 3-acetylvergatic acid (2), as well as five known triterpenoids, two steroids and a flavone. The structures of the compounds were established by spectroscopic analyses. The isolated compounds were tested against standard bacterial strains. Only the new diterpene, 6beta-hydroxyisopimaric acid has strong activity (MIC 9 mug/ml) against S. aureus and (MIC 18 mug/ml) against S. epidermidis as well as against B. subtilis (MIC 9 mug/ml).