Lack of Clinical Manifestations in Asymptomatic Dengue Infection Is Attributed to Broad Down-Regulation and Selective Up-Regulation of Host Defence Response Genes

Yeo, Adeline; Azhar, Nur; Yeow, Wanyi; Talbot, C.; Khan, MOHAMMAD; Shankar, Esaki; Rathakrishnan, Anusyah; Azizan, Azliyati; Wang, Seok; Lee, Siew; Fong, Mun; Manikam, Rishya; Sekaran, Shamala

doi:10.1371/journal.pone.0092240

Lack of Clinical Manifestations in Asymptomatic Dengue Infection Is Attributed to Broad Down-Regulation and Selective Up-Regulation of Host Defence Response Genes

Yeo A. S. L., Azhar N. A., Yeow W., Talbot C. C., Khan M. A., Shankar E. M., ...Daha Fazla

PLOS ONE, cilt.9, sa.4, 2014 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 9 Sayı: 4
Basım Tarihi: 2014
Doi Numarası: 10.1371/journal.pone.0092240
Dergi Adı: PLOS ONE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Bezmiâlem Vakıf Üniversitesi Adresli: Hayır

Özet

Objectives: Dengue represents one of the most serious life-threatening vector-borne infectious diseases that afflicts approximately 50 million people across the globe annually. Whilst symptomatic infections are frequently reported, asymptomatic dengue remains largely unnoticed. Therefore, we sought to investigate the immune correlates conferring protection to individuals that remain clinically asymptomatic.