The beneficial effect of melatonin on chronic cyclosporin A nephrotoxicity in rats


Esrefoglu M. , KURUŞ M., SAHNA E.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, vol.31, no.1, pp.42-44, 2003 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 1
  • Publication Date: 2003
  • Doi Number: 10.1177/147323000303100107
  • Title of Journal : JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
  • Page Numbers: pp.42-44

Abstract

Cyclosporin A (CsA)-induced nephrotoxicity may be the consequence of oxidative stress. Anti-oxidant agents could be useful in reducing CsA toxicity. In this light microscopy study, tubular dilatation, atrophy, vacuolization and tubulointerstitial fibrosis were observed in rats given CsA, whereas in rats given CsA plus melatonin, no histological changes occurred. It is concluded that melatonin could be useful for reducing the nephrotoxic effects of CsA.