Thymoquinone Enhances the Effect of Gamma Knife in B16-F10 Melanoma Through Inhibition of Phosphorylated STAT3

HATİBOĞLU M. A., KOÇYİĞİT A., GÜLER E. M., Akdur K., Khan I., Nalli A., ...Daha Fazla

WORLD NEUROSURGERY, cilt.128, 2019 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 128
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.wneu.2019.04.205
  • Dergi Adı: WORLD NEUROSURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Apoptosis, Brain metastasis, Gamma Knife, Melanoma, Radiation, STAT3, METASTATIC MELANOMA, INDUCED APOPTOSIS, BRAIN METASTASES, NIGELLA-SATIVA, MALIGNANT-MELANOMA, ANTITUMOR-ACTIVITY, SIGNAL TRANSDUCER, TUMOR-FORMATION, CANCER CELLS, EXPRESSION
  • Bezmiâlem Vakıf Üniversitesi Adresli: Evet

Özet

BACKGROUND: Patients with brain metastasis from melanoma have a dismal prognosis with poor survival time. Gamma Knife (GK) is an effective treatment to control brain metastasis from melanoma. Thymoquinone (TQ) has emerged as a potential therapeutic option due to its antiproliferative effects on various cancers. The purpose of the study was to assess the effect of GK on B16-F10 melanoma cells in vitro and intracerebral melanoma in vivo, and its synergistic effect in combination with TQ.