Thymoquinone Enhances the Effect of Gamma Knife in B16-F10 Melanoma Through Inhibition of Phosphorylated STAT3

HATİBOĞLU M. A., KOÇYİĞİT A., GÜLER E. M., Akdur K., Khan I., Nalli A., ...More

WORLD NEUROSURGERY, vol.128, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 128
  • Publication Date: 2019
  • Doi Number: 10.1016/j.wneu.2019.04.205
  • Journal Name: WORLD NEUROSURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Apoptosis, Brain metastasis, Gamma Knife, Melanoma, Radiation, STAT3, METASTATIC MELANOMA, INDUCED APOPTOSIS, BRAIN METASTASES, NIGELLA-SATIVA, MALIGNANT-MELANOMA, ANTITUMOR-ACTIVITY, SIGNAL TRANSDUCER, TUMOR-FORMATION, CANCER CELLS, EXPRESSION
  • Bezmialem Vakıf University Affiliated: Yes

Abstract

BACKGROUND: Patients with brain metastasis from melanoma have a dismal prognosis with poor survival time. Gamma Knife (GK) is an effective treatment to control brain metastasis from melanoma. Thymoquinone (TQ) has emerged as a potential therapeutic option due to its antiproliferative effects on various cancers. The purpose of the study was to assess the effect of GK on B16-F10 melanoma cells in vitro and intracerebral melanoma in vivo, and its synergistic effect in combination with TQ.