Investigation of the Genotoxic, Cytotoxic, Apoptotic, and Oxidant Effects of Olive Leaf Extracts on Liver Cancer Cell Lines.

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Bektay M. Y., Güler E. M., Gökçe M., Kızıltaş M. V.

Turkish journal of pharmaceutical sciences, vol.18, no.6, pp.781-789, 2021 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 6
  • Publication Date: 2021
  • Doi Number: 10.4274/tjps.galenos.2021.03271
  • Journal Name: Turkish journal of pharmaceutical sciences
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, EMBASE, International Pharmaceutical Abstracts, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.781-789
  • Keywords: Olive leaf, hepatocellular carcinoma, oleuropein, oxidative stress, genotoxicity, apoptosis, ANTIOXIDANT ACTIVITY, OLEUROPEIN, POLYPHENOLS, PROLIFERATION, DAMAGE, TREE
  • Bezmialem Vakıf University Affiliated: Yes


Objectives: Hepatocellular carcinoma (HCC) is the seventh most common cancer and the third leading cause of tumor-related deaths worldwide. Mechanisms underlying tumor onset, progression, and metastasis in the case of HCC have not been adequately studied. In this study, we aimed to investigate the genotoxic, cytotoxic, apoptotic and oxidant effects of olive leaf extract (OLE) on HCC cells.