Investigation of the Genotoxic, Cytotoxic, Apoptotic, and Oxidant Effects of Olive Leaf Extracts on Liver Cancer Cell Lines.

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Bektay M. Y., Güler E. M., Gökçe M., Kızıltaş M. V.

Turkish journal of pharmaceutical sciences, cilt.18, sa.6, ss.781-789, 2021 (ESCI, Scopus, TRDizin) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 6
  • Basım Tarihi: 2021
  • Doi Numarası: 10.4274/tjps.galenos.2021.03271
  • Dergi Adı: Turkish journal of pharmaceutical sciences
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, EMBASE, International Pharmaceutical Abstracts, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.781-789
  • Anahtar Kelimeler: Olive leaf, hepatocellular carcinoma, oleuropein, oxidative stress, genotoxicity, apoptosis, ANTIOXIDANT ACTIVITY, OLEUROPEIN, POLYPHENOLS, PROLIFERATION, DAMAGE, TREE
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Bezmiâlem Vakıf Üniversitesi Adresli: Evet

Özet

Objectives: Hepatocellular carcinoma (HCC) is the seventh most common cancer and the third leading cause of tumor-related deaths worldwide. Mechanisms underlying tumor onset, progression, and metastasis in the case of HCC have not been adequately studied. In this study, we aimed to investigate the genotoxic, cytotoxic, apoptotic and oxidant effects of olive leaf extract (OLE) on HCC cells.