The effect of the SIRT1 2827 A > G polymorphism, resveratrol, exercise, age and occupation in Turkish population with cardiovascular disease


IZMIRLI M., GOKTEKIN O., Bacaksiz A. , Uysal O. , Kilic U.

ANATOLIAN JOURNAL OF CARDIOLOGY, cilt.15, ss.103-106, 2015 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 15 Konu: 2
  • Basım Tarihi: 2015
  • Doi Numarası: 10.5152/akd.2014.5214
  • Dergi Adı: ANATOLIAN JOURNAL OF CARDIOLOGY
  • Sayfa Sayısı: ss.103-106

Özet

Objective: Cardiovascular disease (CVD) is the leading cause of death in Europe. One of the candidate molecule affecting epigenetic mechanisms of CVD is the SIRT1, a subclass of sirtuins, is located on the long arm of chromosome 10 (10q21.3). Particularly, the relation between 2827 A>G polymorphism of the SIRT1 positioned on exon 2, leading to conversion of histidine to arginine, and the formation of CVD is not known yet. One of the activator of SIRT1, resveratrol, is also known as a cardioprotective molecule. On the other hand, the parameters including exercise, occupation and age affect CVD. The aim of the present study was to investigate the effect of the rs144124002 (2827 A>G) single nucleotide polymorphisms (SNP) of SIRT1 and exercise-occupation-age parameters on CVD.