MicroRNA 199a Is Downregulated in Patients After Coronary Artery Bypass Graft Surgery and Is Associated with Increased Levels of Sirtuin 1 (SIRT 1) Protein and Major Adverse Cardiovascular Events at 3-Year Follow-Up

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YAMAÇ A. H., HUYUT M. A., Yilmaz E., ÇELİKKALE İ., BACAKSIZ A., Demir Y., ...More

MEDICAL SCIENCE MONITOR, vol.24, pp.6245-6254, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24
  • Publication Date: 2018
  • Doi Number: 10.12659/msm.912065
  • Journal Name: MEDICAL SCIENCE MONITOR
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.6245-6254
  • Keywords: Coronary Artery Bypass, MicroRNAs, Sirtuin 1, Ventricular Function, Left, CHRONIC HEART-FAILURE, ATRIAL-FIBRILLATION, OXIDATIVE STRESS, OUTCOMES, PROTECTION, DISEASE, INJURY, RISK
  • Bezmialem Vakıf University Affiliated: Yes

Abstract

Background: The cardioprotective protein SIRT1 is elevated in patients with coronary artery disease (CAD) to compensate for the disease-related adverse effects, but less is known about the prognostic role of SIRT 1 regulating microRNAs in patients after coronary artery bypass graft (CABG) surgery.