Serum Myeloperoxidase, Paraoxonase and Arylesterase Enzymes Levels in Children with Bronchiectasis


Kiyak M. C., Kahraman F. U., Gedik A. H., Kocyigit A., Cakir F. B., Nursoy M., ...More

HONG KONG JOURNAL OF PAEDIATRICS, vol.27, no.2, pp.126-131, 2022 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 2
  • Publication Date: 2022
  • Journal Name: HONG KONG JOURNAL OF PAEDIATRICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE
  • Page Numbers: pp.126-131
  • Keywords: Arylesterase, Bronchiectasis, Myeloperoxidase, Oxidant, Paraoxonase, DEFICIENCY, INFLAMMATION, DIAGNOSIS
  • Bezmialem Vakıf University Affiliated: Yes

Abstract

Background: The aim of this study was to measure the serum levels of myeloperoxidase (MPO), paraoxonase (PON1) and arylesterase (ARE) in paediatric patients with non-cystic fibrosis bronchiectasis (non-CF BE), and to compare these results with healthy controls. Methods: A total of 101 paediatric patients with non-CF BE and 70 age- and sex-matched healthy controls were enrolled into the study between November 2010 and November 2015. The levels of MPO, PON1 and ARE were measured in all participants. Findings: Compared to controls, MPO levels were significantly lower (p=0.001), while PONI and ARE levels were significantly higher in the patient group (p=0.001). Conclusion: Our study reports that the oxidant and anti-oxidant enzyme levels in non-CF BE differ from healthy controls; thus, suggesting a role in non-CF BE pathophysiology.