Akademik Veri Yönetim Sistemi
22.Uluslararası Doğu Akdeniz Aile Hekimliği Kongresi, 11 - 14 Mayıs 2023, ss.212-214, (Özet Bildiri)
Selenium Levels and Type 2 Diabetes Mellitus; Can We
Make Sense of It?
1Zeyneb
İrem YÜKSEL SALDUZ
https://orcid.org/0000-0001-7730-1029
Adress: 1Bezmialem Medical Faculty
Department of Family Medicine
Adnan Menderes Bulvarı (Vatan Cad.) P.K. 34093 Fatih /
İstanbul
E-mail: iremsalduz@hotmail.com Telephone: 05556367824
Aim:
Se (Selenium) is one of the most essential trace elements for human health. The
association between serum selenium levels and T2DM (type 2 diabetes mellitus)
is controversial. Selenium supplementation has been shown to reduce
insulin serum levels and HOMA-IR (Homeostatic Model Assessment for Insulin
Resistance) levels in patients with IR (insulin resistance). The aim of this
study to investigate the relationship between selenium deficiency and insulin
resistance (1-3).
Material and Methods: A total of 161 patients who applied for general check-up
evaluation were included in the study. The HOMA-IR index was obtained as
fasting insulin (mIU/L) × fasting glucose (mg/dL)/405. BMI (Body mass index)
was calculated kilograms divided by the square of height in meters. Patients
were divided into 2 groups according to the Selenium levels that cut-off level
63 µg/l. The biochemical and hemogram data of the patients were examined. Data
were analyzed using SPSS® software for Window® version 22 (SPSS Inc., Chicago,
IL, USA). The differences between groups were compared using student-T test and
chi square tests. Data were expressed either as mean and standard deviation.
The statistical significance was set at the P value of ≤ 0,05.
Results: The mean age of the patients was 39±13 years. 72% (n:116) of the
patients were women. The HOMA-IR value of the patients was above 2,5 in 57
patients. Forty-five patients have low Se levels. The mean of BMI was 21,07
±11,4. Among the laboratory data, urea, BUN (blood urea nitrogen), creatinine,
GFR (glomerular filtration rate), albumin, Mg (magnesium), LDL (Low density
lipoprotein), Ca (calcium), Vitamin C, HCT (hematocrit), HGB (hemoglobin) were
statistically significant and clinically insignificant between the groups.
However, vitamin D and HOMA-IR were statistically and clinically significant
between the groups (p≤ 0,05) (Table 1). The selenium value was found to
be low in 40% and 21% of the patients with insulin resistance and without
insulin resistance respectively (p: 0,016). In patients with insulin
resistance, HbA1c values were high as prediabetic (p: 0,0001).
Conclusions: Se, an essential trace element, is recommended as a supplement
to prevent conditions such as diabetes. However, recent studies have also shown
that supplemental Se intake is positively associated with the prevalence of
diabetes. For this reason, it is important for preventive medicine to carry out
comprehensive routine blood checks of patients. A simple and inexpensive Se
supplement at the right time and in the right amount may be an appropriate
measure in diabetes prevention.
Keywords: Selenium, diabetes, supplementation
Table 1: Mean values of the variables in the groups.
|
|
Selenium
(<63 µg/l) |
Selenium (63-160 µg/l) |
P values |
|
HOMA-IR |
3,09± 1,9 |
2,33 ±1,3 |
0,006* |
|
Vitamin D (20-70
µg/L) |
14,3 ±8,3 |
20,3± 11,3 |
0,001* |
|
Urea (12,8-42,8
mg/dl) |
22,1± 5,6 |
26,9±6,2 |
0,001 |
|
BUN (6-20 mg/dl) |
10,3±2,6 |
12,6±2,9 |
0,001 |
|
Creatinine
(0,6-1,3 mg/dl) |
0,72±0,1 |
0,78±0,16 |
0,028 |
|
EGFR (<90 ml/min/1,73
m2) |
108,2±13,7 |
100,7±18,5 |
0,014 |
|
Albumin (3,5-5
g/dl) |
4,6±0,3 |
4,7±0,2 |
0,001 |
|
Magnesium
(1,6-2,6 mg/dl) |
1,8±0,1 |
1,9±0,1 |
0,017 |
|
LDL (<100
mg/dl) |
110±35 |
123±35 |
0,047 |
|
Calcium (8,3-10,6
mg/dl) |
9,5±0,3 |
9,7±0,4 |
0,042 |
|
Vitamin C (5-15
mg/l) |
12,4±4,9 |
14,9±5,2 |
0,005 |
|
HCT (Male 40-52
Female 35,5-48 %) |
39,9±3,3 |
41,3±3,9 |
0,043 |
|
HGB (Male
14,1-17,5 Female 12,2-16,2 g/dl) |
13,0±1,4 |
13,6±1,6 |
0,038 |
*Clinically and statistically significant.
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