The role of plasma exchange in acute liver failure of autoimmune etiology


Gokce S., Cermik B. B. , KUTLU N. O. , Ocak I.

TURKISH JOURNAL OF PEDIATRICS, vol.63, no.2, pp.329-333, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 63 Issue: 2
  • Publication Date: 2021
  • Doi Number: 10.24953/turkjped.2021.02.019
  • Title of Journal : TURKISH JOURNAL OF PEDIATRICS
  • Page Numbers: pp.329-333

Abstract

Background. Autoimmune hepatitis (AIH) is characterized by increased immunoglobulin G (IgG) levels, the presence of autoantibodies, and various degrees of lymphocyte predominant inflammation and fibrosis histologically. Immunosuppressive therapy induces remission in approximately 80% of those affected. However, liver transplantation is indicated in patients with acute liver failure with encephalopathy at presentation. Liver supporting systems, including plasma exchange (PE) allow bridging patients to transplantation or spontaneous recovery in the setting of liver failure. The role of these systems has not been assessed in children with liver failure of autoimmune etiology.