Psoriasisli Hastada Büllöz Pemfigoid Gelişimi ve Siklosporin ile Ortak Tedavi.

Küçük Ö. S.

türkderm, vol.44, pp.167-169, 2010 (Peer-Reviewed Journal)

  • Publication Type: Article / Article
  • Volume: 44
  • Publication Date: 2010
  • Journal Name: türkderm
  • Page Numbers: pp.167-169


The concomitant occurrence of psoriasis and bullous pemphigoid has been described previously, but the pathogenic mechanism of this relationship is still unknown. We describe a 34-year-old woman with a 22-year history of plaque-type psoriasis. On the third day of hospitalization, disseminated tense bullae developed on her neck and upper extremities. Histologic examination of biopsy specimen obtained from a vesicular lesion demonstrated a subepidermal blister. Direct immunofluorescence revealed IgG and C3 deposition in a linear pattern at the basement membrane zone. Both diseases were successfully treated with cyclosporine. However, the coexistence of these conditions represents a difficult therapeutic challenge.