Investigation of the roles of new antiepileptic drugs’ and serum BDNF levels in efficacy and safety monitoring and quality of life: a clinical research


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Demir M., Akarsu E. O. , Dede H. Ö. , Bebek N., Yıldız S. Ö. , Baykal B., ...More

Current Clinical Pharmacology, vol.15, no.1, pp.49-63, 2020 (Journal Indexed in ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 1
  • Publication Date: 2020
  • Doi Number: 10.2174/1574884714666190312145409
  • Title of Journal : Current Clinical Pharmacology
  • Page Numbers: pp.49-63
  • Keywords: Epilepsy, new antiepileptic drugs, TDM, safety, QOLIE-31, BDNF, efficacy, NEUROTROPHIC FACTOR, PHARMACOKINETIC INTERACTIONS, ILAE-COMMISSION, BRAIN, EPILEPSY, LAMOTRIGINE, EMPLOYMENT, MECHANISM, SEIZURES

Abstract

Objective: We aimed to determine the therapeutic drug monitoring (TDM) features and the relation to Brain-Derived Neurotrophic Factor (BDNF) of frequently used new antiepileptic drugs (NADs) including lamotrigine (LTG), oxcarbazepine (OXC), zonisamide (ZNS) and lacosamide (LCM). Moreover, we investigated their effect on the quality of life (QoL).