Identification of highly conserved, serotype-specific dengue virus sequences: implications for vaccine design


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Chong L. C. , Khan A. M.

BMC GENOMICS, vol.20, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20
  • Publication Date: 2019
  • Doi Number: 10.1186/s12864-019-6311-z
  • Title of Journal : BMC GENOMICS
  • Keywords: Dengue virus, Cross-reactivity, Serotype-specific, Sequence conservation, Entropy, Mutual information, Immune targets, Vaccine design, T-CELL RESPONSES, PEPTIDE, CD4(+), RECOGNITION, MECHANISMS, EPITOPES, BINDING, DATABASE, TCR

Abstract

Background: The sequence diversity of dengue virus (DENV) is one of the challenges in developing an effective vaccine against the virus. Highly conserved, serotype-specific (HCSS), immune-relevant DENV sequences are attractive candidates for vaccine design, and represent an alternative to the approach of selecting pan-DENV conserved sequences. The former aims to limit the number of possible cross-reactive epitope variants in the population, while the latter aims to limit the cross-reactivity between the serotypes to favour a serotype-specific response. Herein, we performed a large-scale systematic study to map and characterise HCSS sequences in the DENV proteome.