Merosin-negative congenital muscular dystrophy: Diffusion-weighted imaging findings of brain

Alkan A., SIGIRCI A., KUTLU R., ASLAN M., DOGANAY S., YAKINCI C.

JOURNAL OF CHILD NEUROLOGY, vol.22, no.5, pp.655-659, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 5
  • Publication Date: 2007
  • Doi Number: 10.1177/0883073807303219
  • Journal Name: JOURNAL OF CHILD NEUROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.655-659
  • Keywords: muscular dystrophy, magnetic resonance imaging, PERIPHERAL NERVOUS-SYSTEM, CEREBRAL WHITE-MATTER, INVOLVEMENT, DEFICIENCY
  • Bezmialem Vakıf University Affiliated: No

Abstract

Merosin-negative congenital muscular dystrophy is a rare genetic disease of childhood involving the central and peripheral nervous system. There were high signal intensities throughout the centrum semiovale, periventricular, and subcortical white matters on T2-veighted images in a 4-year-old girl with merosin-negative congenital Muscular dystrophy. An apparent diffusion coefficient map revealed increased signal intensity and apparent diffusion coefficient values in the periventricular and deep white matters. It may be attributable to increased water content in the white matter because of an abnormal blood-brain barrier rather than to decreased or abnormal myelination.