Montelukast Protects Axial Pattern Rat Skin Flaps Against Ischemia/Reperfusion Injury

Gideroglu K., Yilmaz F., Aksoy F., Bugdayci G., Saglam I., Yimaz F.

JOURNAL OF SURGICAL RESEARCH, vol.157, no.2, pp.181-186, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 157 Issue: 2
  • Publication Date: 2009
  • Doi Number: 10.1016/j.jss.2008.07.031
  • Journal Name: JOURNAL OF SURGICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.181-186
  • Bezmialem Vakıf University Affiliated: Yes

Abstract

Background. Recent studies have shown that neutrophils play an important role in the pathogenesis of reperfusion injury. Using an inferior epigastric artery skin flap as a flap ischemia/reperfusion (I/R) injury model, we investigated whether the administration of montelukast sodium, a selective reversible cysteinyl leukotriene 1 (Cy5LT1) receptor antagonist, decreases neutrophil infiltration and promotes flap survival.