Early stage T1-weighted perfusion magnetic resonance imaging: a factor that predicts local control response in patients with meningioma who underwent gamma-knife radiosurgery

Abdallah A., SEYİTHANOĞLU M. H., Papaker M., Aralasmak A., YAPAR S., Baloglu G.

NEUROLOGICAL RESEARCH, vol.44, no.12, pp.1113-1121, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 12
  • Publication Date: 2022
  • Doi Number: 10.1080/01616412.2022.2112377
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, MEDLINE
  • Page Numbers: pp.1113-1121
  • Keywords: Gamma knife stereotactic radiosurgery, meningioma, dynamic contrast-enhanced magnetic resonance imaging, K-trans, post-GKRS follow-up, STEREOTACTIC RADIOSURGERY, TUMOR-CONTROL, RADIATION, SURGERY, SERIES, MRI
  • Bezmialem Vakıf University Affiliated: Yes


Background Gamma-knife radiosurgery (GKRS) is an alternative treatment option for selected intracranial meningiomas. The study's aim is to demonstrate the advantages of T1-weighted perfusion magnetic resonance imaging (T1-PMRI) by measuring the volume transfer coefficient (K-trans) values in the prediction of local response for patients with meningioma who have undergone GKRS consecutively. Methods The data of patients diagnosed radiologically with WHO grade 1 intracranial meningiomas was collected prospectively. The patients who were treated consecutively with GKRS at our institution (September 2017-September 2018) were included. After GKRS, the patients were followed up at the defined periods with routine contrast-enhanced MRI and T1-PMRI by measuring the K-trans. The comparison between the pre-treatment and third-month post-treatment (PO3M) K-trans was done using the Wilcoxon signed-rank test. Results Thirty-one patients with 36 tumors have undergone GKRS. Twenty-two patients were female. The mean age was 55.3 years. The mean pre-GKRS volume was 7.67 ccs. The mean 50% radiation isodose was 12.2 Gy. The local tumor control rate was 100%. Fourteen tumors were regressed fully at the last MRI. PO3M K-trans decreased when compared with the pre-GKRS values (p < 0.0001). However, the numerical decrease in tumor volumes on contrast-enhanced MRI was not statistically significant (p = 0.117). Conclusion Changes between K-trans on PO3M and pre-GKRS T1-PMRI were more useful in determining the early response to GKRS in patients with meningioma than volumetric changes. Therefore, K-trans should be taken as a reference to predict the early response to GKRS in follow-up imaging scans.