A fatal interstitial lung disease in an anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibody negative patient with juvenile dermatomyositis

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YEŞİLBAŞ O., Yildiz M., Yozgat C. Y., Tahaoglu I., YAZAN H., ÇAKIR E., ...More

TURKISH JOURNAL OF PEDIATRICS, vol.63, no.5, pp.903-908, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 63 Issue: 5
  • Publication Date: 2021
  • Doi Number: 10.24953/turkjped.2021.05.018
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.903-908
  • Keywords: anti-melanoma differentiation associated gene 5, child, juvenile dermatomyositis, interstitial lung disease, rapidly progressive interstitial lung disease, FEATURES
  • Bezmialem Vakıf University Affiliated: Yes


Background. Juvenile dermatomyositis associated interstitial lung disease, rarely seen in pediatric age groups, has adverse effects on survival. Anti-melanoma differentiation associated gene 5, one of the identified autoantibodies in juvenile dermatomyositis, preferentially affects the lung tissue and may cause rapidly progressive interstitial lung disease. It is a major cause of mortality in juvenile dermatomyositis. In this case report, we present a pediatric patient diagnosed with juvenile dermatomyositis without anti-melanoma differentiation associated gene 5 antibody positivity.