A fatal interstitial lung disease in an anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibody negative patient with juvenile dermatomyositis

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YEŞİLBAŞ O. , Yildiz M. , Yozgat C. Y. , Tahaoglu I., YAZAN H. , ÇAKIR E. , ...More

TURKISH JOURNAL OF PEDIATRICS, vol.63, no.5, pp.903-908, 2021 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 63 Issue: 5
  • Publication Date: 2021
  • Doi Number: 10.24953/turkjped.2021.05.018
  • Page Numbers: pp.903-908
  • Keywords: anti-melanoma differentiation associated gene 5, child, juvenile dermatomyositis, interstitial lung disease, rapidly progressive interstitial lung disease, FEATURES


Background. Juvenile dermatomyositis associated interstitial lung disease, rarely seen in pediatric age groups, has adverse effects on survival. Anti-melanoma differentiation associated gene 5, one of the identified autoantibodies in juvenile dermatomyositis, preferentially affects the lung tissue and may cause rapidly progressive interstitial lung disease. It is a major cause of mortality in juvenile dermatomyositis. In this case report, we present a pediatric patient diagnosed with juvenile dermatomyositis without anti-melanoma differentiation associated gene 5 antibody positivity.