Association of adenosine deaminase, superoxide dismutase, and catalase activities with Helicobacter pylori

Bulbuloglu E., Inanc F., Bakaris S., Kantarceken B., Cetinkaya A., Caglar R., ...More

DIGESTIVE DISEASES AND SCIENCES, vol.50, no.12, pp.2296-2299, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 50 Issue: 12
  • Publication Date: 2005
  • Doi Number: 10.1007/s10620-005-3050-6
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2296-2299
  • Keywords: Helicobacter pylori, adenosine deaminase, superoxide dismutase, HUMAN GASTRIC-MUCOSA, LYMPHOID FOLLICLES, XANTHINE-OXIDASE, INFECTION
  • Bezmialem Vakıf University Affiliated: No


Our purpose was to investigate associations between adenosine deaminase (ADA), superoxide dismutase (SOD), and catalase (CAT) activities and H. pylori. Ninety-nine patients were studied. Eight antral mucosal biopsies were taken for biochemical assessment of ADA, CAT, AND SOD activity and histological assessment. H. pylori density wAS evaluated according to the updated Sydney system. Patients were divided into three groups according to Sydney classification. ADA activity was found to be higher in patients having H. pylori in the present study. Also, ADA activity was higher in patients with a severe density of H. pylori. SOD level was found to be significantly higher with increased H. pylori density in our study (P < 0.05). In addition, SOD activity was higher in H. Pylori-positive than H. pylori-negative patients. We did not find CAT activity in some antral tissue specimens. The significantly high levels of ADA activity in patients with H. pylori infection may reflect the regulator role of ADA in acid secretion. The higher ADA level with increased H. pylori density and H. pylori positivity indicate the probable malign lymphoid process of the stomach. But these findings must be confirmed with larger studies that include different gastric lesions.