Lipid Profile and Inflammation in Degenerative Valvular Disease

Yamak M., Şar F., Akarsu Ö., Gürsu M., Hacıoğlu B., Ataoğlu H. E., ...More

HASEKI TIP BULTENI, vol.53, no.1, pp.62-66, 2015 (Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 53 Issue: 1
  • Publication Date: 2015
  • Doi Number: 10.4274/haseki.2036
  • Journal Name: HASEKI TIP BULTENI
  • Journal Indexes: Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.62-66
  • Bezmialem Vakıf University Affiliated: Yes


Aim: Degenerative valvular heart disease (DVHD) may cause serious cardiac problems and mortality. Determination of the factors related to DVHD may render possible the prevention and/or slowing down the progression of DVHD. In this study, we evaluated the relationship of DVHD with lipid profile, microalbuminuria and high sensitive C-reactive protein (hsCRP) levels. Methods: 50 patients (age=65.6±12.4 years) with DVHD were compared with the control group including 20 patients (age=57.3±13.9 years) with left ventricle hypertrophy, but no DVHD. Microalbuminuria, blood lipid parameters and hsCRP levels were measured besides routine biochemical tests. Clinical, laboratory and echocardiographic findings were compared between the groups. Results: Total cholesterol, HDL-cholesterol and LDL-cholesterol levels were significantly higher in DVHD group (215.26±48.59 mg/dL vs. 177.45±22.47 mg/dL, p=0.001; 45.04±11.03 mg/dL vs. 38.90±11.82 mg/dL, p=0.043 and 138.49±40.69 mg/dL vs. 114.26±16.07 mg/dL, p=0.001) compared with control group. hsCRP and microalbuminuria levels were relatively higher in DVHD group. Conclusion: Hyperlipidaemia is related to DHVD development, and the progress of DHVD may be related to the inflammatory process. Elevated hsCRP levels may be an indicator of pathologies active in DVHD development. Routine echocardiographic analysis in hypertensive patients with high hsCRP and LDL-cholesterol levels might be useful for screening of DVHD. (The Me­di­cal Bul­le­tin of Ha­se­ki 2015; 53: 62-6)