Dose and time dependent ototoxicity of aspartame in rats.

Ozturan O. , Dogan R. , TUGRUL S. , Gedik O. , SJOSTRAND A. P. , Yildirim Y. S.

Acta oto-laryngologica, vol.137, no.4, pp.421-425, 2017 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 137 Issue: 4
  • Publication Date: 2017
  • Doi Number: 10.1080/00016489.2016.1256498
  • Title of Journal : Acta oto-laryngologica
  • Page Numbers: pp.421-425
  • Keywords: ABR, aspartame, DPOAE, ototoxicity, SWEETENERS, SAFETY


Conclusion: Low-dose administration of Aspartame (Ap) did not produce a significant ototoxic effect at the end of the 6th month. However, duration of the ototoxic effect is shortened and severity of the effect is increased as dose and duration of Ap administration is increased.