Dose and time dependent ototoxicity of aspartame in rats.

Ozturan O., Dogan R., TUGRUL S., Gedik O., SJOSTRAND A. P., Yildirim Y. S.

Acta oto-laryngologica, cilt.137, sa.4, ss.421-425, 2017 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 137 Sayı: 4
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1080/00016489.2016.1256498
  • Dergi Adı: Acta oto-laryngologica
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.421-425
  • Anahtar Kelimeler: ABR, aspartame, DPOAE, ototoxicity, SWEETENERS, SAFETY
  • Bezmiâlem Vakıf Üniversitesi Adresli: Evet

Özet

Conclusion: Low-dose administration of Aspartame (Ap) did not produce a significant ototoxic effect at the end of the 6th month. However, duration of the ototoxic effect is shortened and severity of the effect is increased as dose and duration of Ap administration is increased.