Dose and time dependent ototoxicity of aspartame in rats.

Ozturan O. , Dogan R. , TUGRUL S. , Gedik O. , SJOSTRAND A. P. , Yildirim Y. S.

Acta oto-laryngologica, cilt.137, sa.4, ss.421-425, 2017 (SCI Expanded İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 137 Konu: 4
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1080/00016489.2016.1256498
  • Dergi Adı: Acta oto-laryngologica
  • Sayfa Sayıları: ss.421-425


Conclusion: Low-dose administration of Aspartame (Ap) did not produce a significant ototoxic effect at the end of the 6th month. However, duration of the ototoxic effect is shortened and severity of the effect is increased as dose and duration of Ap administration is increased.