Novel approach for the prevention of contrast nephropathy


Colbay M., Yuksel S., Uslan I., Acarturk G., Karaman Ö. , Bas O., ...More

EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, vol.62, no.1, pp.81-89, 2010 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 62 Issue: 1
  • Publication Date: 2010
  • Doi Number: 10.1016/j.etp.2009.02.119
  • Title of Journal : EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY
  • Page Numbers: pp.81-89
  • Keywords: Caffeic acid phenethyl ester, N-acetylcystein, Contrast medium, Nephropathy, Oxidant-antioxidant status, ACID PHENETHYL ESTER, CISPLATIN-INDUCED NEPHROTOXICITY, ACUTE-RENAL-FAILURE, N-ACETYLCYSTEINE, REPERFUSION INJURY, RISK-FACTORS, TOXICITY, PHARMACOKINETICS, SAFETY, AGENTS

Abstract

Objective: To date, there is no effective treatment of contrast medium (CM)-induced nephropathy. Multiple Studies documented a protective role of hydration and N-acetylcystein (NAC) as prophylactic agents against CM-induced nephropathy in a high-risk population. In the present Study, we investigated a new antioxidant agent, caffeic acid phenethyl ester (CAPE), and compare with NAC against contrast nephropathy.