Ovarian cortical transplantation may be an alternative to hormone therapy in patients with early climacterium

Kiran G., Kiran H., Coban Y. K., Guven A. M.

Fertility and Sterility, vol.84, no.5, 2005 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 84 Issue: 5
  • Publication Date: 2005
  • Doi Number: 10.1016/j.fertnstert.2005.05.032
  • Journal Name: Fertility and Sterility
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Fresh autologous transplant, Long-term follow-up, Ovary
  • Bezmialem Vakıf University Affiliated: No


Objective: To discuss the 18-month follow-up results of fresh ovarian cortical tissue transplant. Design: Case study. Setting: Academic medical center. Patient(s): A 46-year-old patient who was operated on for uterine fibroids, and who then received an ovarian tissue transplant in July 2003. Intervention(s): Serum hormone levels were measured at 3-month intervals. Main Outcome Measure(s): Follicular development evident by ultrasound examination; serum hormone levels (FSH, LH, E2). Result(s): Preoperative and 3rd-, 6th-, 9th-, 12th-, 15th-, and 18th-month hormone levels were, respectively, as follows: FSH: 9.06, 79.5, 13.7, 16.66, 51.91, 44.37, and 24.17 mIU/mL; LH: 5.91, 33.92, 8.78, 21.83, 38.31, 40.85, and 22.4 mIU/mL; E2: 166, 46, 48, 117, 31, 14.4, and 137.7 pg/mL. Folliculogenesis was confirmed by ultrasonography at the 6th, 9th, and 18th months during the follow-up period. Conclusion(s): Fresh ovarian autotransplantation may be a logical alternative for hormonal support for a specific patient group. ©2005 by American Society for Reproductive Medicine.