IN VITRO GENOTOXICITY OF CALCIUM PHOSPHATE-BASED BONE SUBSTITUTE MATERIAL ON HUMAN PERIPHERAL MONONUCLEAR LEUKOCYTES

Altay M. A. , Erturk C., KOÇYİĞİT A. , Taskin A., Celik H.

ACTA MEDICA MEDITERRANEA, vol.29, no.4, pp.723-729, 2013 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 4
  • Publication Date: 2013
  • Title of Journal : ACTA MEDICA MEDITERRANEA
  • Page Numbers: pp.723-729

Abstract

Background and aim: Calcium phosphate-based bone substitute materials, also called calcium phosphate cements (CPCs), are widely used in orthopedic surgery. However, the reported results regarding the genotoxicity using these materials are inadequate in literature. We evaluated the DNA damaging effects of a CPC on peripheral mononuclear leukocyte cultures.