IN VITRO GENOTOXICITY OF CALCIUM PHOSPHATE-BASED BONE SUBSTITUTE MATERIAL ON HUMAN PERIPHERAL MONONUCLEAR LEUKOCYTES

Altay M. A. , Erturk C., KOÇYİĞİT A. , Taskin A., Celik H.

ACTA MEDICA MEDITERRANEA, cilt.29, ss.723-729, 2013 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 29 Konu: 4
  • Basım Tarihi: 2013
  • Dergi Adı: ACTA MEDICA MEDITERRANEA
  • Sayfa Sayıları: ss.723-729

Özet

Background and aim: Calcium phosphate-based bone substitute materials, also called calcium phosphate cements (CPCs), are widely used in orthopedic surgery. However, the reported results regarding the genotoxicity using these materials are inadequate in literature. We evaluated the DNA damaging effects of a CPC on peripheral mononuclear leukocyte cultures.