Research Information System
9th International Medicine and Health Sciences Researches Congress, Ankara, Turkey, 18 - 19 March 2022, pp.211-212
Alzheimer's
disease is a neurodegenerative disease characterized by progressive memory
loss, which occurs as a result of damage to our central nervous system,
consisting of the brain and spinal cord, due to many hereditary and environmental
factors. Many factors such as amyloid beta accumulation, glutamate
excitotoxicity, tau proteins, neurofibrillary tangles, synapse-neuron loss are
involved in the pathogenesis of Alzheimer's disease. Prolonged exposure to some
heavy metals such as inflammation, oxidative stress, pesticides, insulin
resistance, cholesterol, aluminum and mercury increases the risk of developing
the disease. In addition, carrying the apolipoprotein E4 gene is one of the
risk factors. This situation shows us that Alzheimer's does not only occur with
aging, but also environmental factors have a great effect on the formation of
Alzheimer's disease. There is no definitive nutritional model that completely
cures Alzheimer's disease. However, it is known that the Mediterranean diet
protects memory, increases cognitive functions and has a preventive effect on
risk factors that may cause Alzheimer's. This diet is still very popular today,
as it is predominantly white meat instead of red meat, rich in various fruits
and vegetables, limited in animal fats and saturated fats, and rich in
vegetable unsaturated fats. In particular, medium-chain fatty acids are rapidly
absorbed from the portal circulation and long-chain fatty acids have a
cognitive function-enhancing effect due to their anti-inflammatory effects.
With these features, the Mediterranean diet has an anti-inflammatory and
protective effect from free radicals. The purpose of this compilation study;
The source of Alzheimer's disease is to explain the environmental and genetic
factors and the changes that occur in the organism during the course of the
disease. In this context, it is to give information about how diet, various
elements, microbiota and many other factors affect the course of Alzheimer's
disease.