Gingival crevicular fluid levels of monocyte chemoattractant protein-1 in patients with aggressive periodontitis

Gunpinar Ş., Alptekin N., Dundar N.

Oral Diseases, vol.23, no.6, pp.763-769, 2017 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 6
  • Publication Date: 2017
  • Doi Number: 10.1111/odi.12658
  • Journal Name: Oral Diseases
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.763-769
  • Keywords: aggressive periodontitis, enzyme-linked immunosorbent assay, gingival crevicular fluid, monocyte chemoattractant protein-1
  • Bezmialem Vakıf University Affiliated: No

Abstract

© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons LtdObjectives: The purpose of this study was to investigate the gingival crevicular fluid (GCF) levels of monocyte chemoattractant protein (MCP)-1 in aggressive periodontitis (AgP) and whether GCF MCP-1 levels differ among localized (L) AgP and generalized (G) AgP. Material and Methods: A total of 160 subjects including 80 AgP and 80 age- and gender-matched periodontally healthy (H) controls were recruited in this cross-sectional study (NCT02927704). GCF samples were collected from 160 patients including 50 LAgP, 30 GAgP, and 80 H. Volume of GCF was measured by Periotron 8000®, and enzyme-linked immunosorbent assay was used to assess MCP-1 levels. Results: Compared to H controls, all clinical parameters and total amounts (pg 30 s−1) of MCP-1 were significantly higher in subjects with LAgP and GAgP (P < 0.05). Although concentrations of GCF MCP-1 did not differ between LAgP and GAgP (P > 0.05), total amounts of MCP-1 were higher in GAgP than LAgP (P < 0.05). Conclusion: It can be concluded that the total amount of MCP-1 level in GCF may be a potential determinant in AgP subjects. Increased MCP-1 levels in line with the degree of periodontal destruction in GAgP patients reveal that MCP-1 can be used to understand the disease pathogenesis of LAgP and GAgP.