Cytotoxic and DNA damaging activity of some aporphine alkaloids from Stephania dinklagei

Goren A. C., ZHOU B., Kingston D.

PLANTA MEDICA, cilt.69, sa.9, ss.867-868, 2003 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 69 Sayı: 9
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1055/s-2003-43224
  • Dergi Adı: PLANTA MEDICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.867-868
  • Bezmiâlem Vakıf Üniversitesi Adresli: Hayır

Özet

Six aporphine alkaloids, liriodenine, corydine, isocorydine, ather-ospermidine, stephalagine and dehydrostephalagine, were isolated by bioassay-guided fractionation of the EtOH extract of the stems of Stephania dinklagei. Liriodenine showed strong cytotoxic activity while corydine and atherospermidine showed DNA damaging activity. Dehydrostephalagine and atherospermidine were isolated from this plant for the first time.