Bullous Pemphigoid in a Patient with Psoriasis Treated with Cydosporine


ULUSAL H. A. , Su O. , CEBECI F., SAKIZ D., Onsun N.

TURKDERM-ARCHIVES OF THE TURKISH DERMATOLOGY AND VENEROLOGY, cilt.44, ss.167-169, 2010 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 44 Konu: 3
  • Basım Tarihi: 2010
  • Doi Numarası: 10.4274/turkderm.44.167
  • Dergi Adı: TURKDERM-ARCHIVES OF THE TURKISH DERMATOLOGY AND VENEROLOGY
  • Sayfa Sayısı: ss.167-169

Özet

The concomitant occurrence of psoriasis and bullous pemphigoid has been described previously, but the pathogenic mechanism of this relationship is still unknown. We describe a 34-year-old woman with a 22-year history of plaque-type psoriasis. On the third day of hospitalization, disseminated tense bullae developed on her neck and upper extremities. Histologic examination of biopsy specimen obtained from a vesicular lesion demonstrated a subepidermal blister. Direct immunofluorescence revealed IgG and C3 deposition in a linear pattern at the basement membrane zone. Both diseases were successfully treated with cyclosporine. However, the coexistence of these conditions represents a difficult therapeutic challenge. (Turkderm 2010; 44: 167-9)