Effects of Different Concentrations of Injectable Collagenase Enzyme on Capsular Tissue Around Silicone Implants: A Preliminary Experimental Study for the Development of a New Treatment Strategy

Yesiloglu N., Temiz G., Sarici M., YILDIZ K. , Sirinoglu H., Guvercin E., ...More

AESTHETIC PLASTIC SURGERY, vol.40, no.1, pp.164-173, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 1
  • Publication Date: 2016
  • Doi Number: 10.1007/s00266-015-0600-y
  • Page Numbers: pp.164-173


In recent studies, collagen organization was blamed for the formation of capsular contracture which is still a challenging problem after silicone implant-based breast operations. In this study, effects of different concentrations of collagenase enzyme derived from Clostridium histolyticum on the capsular tissue formation around the silicone implants were investigated. The injectable form of collagenase has a routine clinical use in the treatment of both Dupuytren's and Peyronie's diseases.