Use of Mesna in the treatment of ossicular chain fixation related to tympanosclerosis; prospective, clinical study.

Eren S. B., Dogan R., Vural Ö., Tugrul S., Yenigun A., Calım Ö. F., ...More

American journal of otolaryngology, vol.41, no.4, pp.102506, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 41 Issue: 4
  • Publication Date: 2020
  • Doi Number: 10.1016/j.amjoto.2020.102506
  • Journal Name: American journal of otolaryngology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, Biotechnology Research Abstracts, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.102506
  • Keywords: Mesna, Tympanosclerosis, Conductive hearing loss, SURGICAL-TREATMENT, HEARING, MOBILITY, STAPES
  • Bezmialem Vakıf University Affiliated: Yes


Objective: Mesna is a thiol compound effective in the connective tissue, which is used for its chemical dissector, mucolytic, mucosal damage preventive and antioxidant effects. The aim of this study was to investigate Mesna's effects in easy dissection in type 4 tympanosclerosis cases and in the prevention of formation of new sclerotic plaques.