Synthesis and cytotoxic activities of transition-metal complexes of a binaphthyl-linked bipyridine ligand

Beynek N., Ulucam G., Benkli K.

TRANSITION METAL CHEMISTRY, vol.34, no.3, pp.289-292, 2009 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 3
  • Publication Date: 2009
  • Doi Number: 10.1007/s11243-009-9192-1
  • Journal Name: TRANSITION METAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.289-292
  • Bezmialem Vakıf University Affiliated: No

Abstract

A binaphthyl-linked bipyridyl compound, 1,1'-bis(6-methyl-6'-oxymethylenyl-2,2'-bipyridine)binaphthyl, (L) has been synthesised and used as a ligand for the formation of Cu(II), Ni(II), and Co(II) complexes. The ligand and its transition-metal complexes were characterized by physico-chemical and spectroscopic methods. The complexes were also investigated for cytotoxic activity. The cytotoxicity of complexes, CuL(ClO(4))(2), NiL(ClO(4))(2)(H(2)O), CoL(ClO(4))(2), were tested in vitro applying seven well-characterized human tumor cell lines, MCF7, EVSA-T, WIDR, IGROV, M19 MEL, A498, H226, and the microculture sulforhodamine B (SRB) test. All complexes show a very high cytotoxicity (ID(50) < 250 ng/ml) in these cell lines.