Relationship of CTLA4 and CD28 polymorphisms with lung involvement, HRCT findings and pulmonary function tests in Turkish patients with ankylosing spondylitis


Okyaltirik F. , Rezvani A. , Turan S., Uysal O. , YAKAR F., SÖZGEN H., et al.

CLINICAL RESPIRATORY JOURNAL, cilt.11, ss.593-601, 2017 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 11 Konu: 5
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1111/crj.12388
  • Dergi Adı: CLINICAL RESPIRATORY JOURNAL
  • Sayfa Sayısı: ss.593-601

Özet

Background and AimsAnkylosing spondylitis (AS) is a multisystem disorder with ocular, pulmonary, and cardiovascular involvement. The incidence of pulmonary involvement varies from 1 to 52%. Abnormal T-cell function-derived immune responses are involved in AS pathogenesis. Numerous genes such as CTLA4 and CD28 control T-cell functions. In this study, we aimed to address the relationship between CTLA4 and CD28 polymorphisms and lung involvement in Turkish patients with AS.