Akademik Veri Yönetim Sistemi
Turk Anesteziyoloji ve Reanimasyon Dernegi Dergisi, cilt.34, sa.2, ss.97-102, 2006 (Scopus, TRDizin)
It became routine application to manage the anxiety of the patient before the operation with appropriate premedication during surgical, diagnostic and invasive procedures. Recently, alfa2 agonists play an important role in premedication. The study was designed to assess the effects of iv dexmedetomidine on peroperative haemodynamics, propofol consumption and postoperative recovery when used as a premedication agent in patients undergoing spinal surgery. Group D received iv dexmedetomidine 0.63 μg kg-1 as a premedication in a 15-min period. The same volume of isotonic solution was administered to the control group. Anaesthesia was induced with propofol and was maintained with propofol infusion, fentanyl and cisatracurium. Statistical analysis was done with Mann-Whitney U, x2, Student's-t and Friedman test. Induction of anaesthesia with propofol was rapid in the presence of dexmedetomidine. The time for BIS to reach 60 was significantly shorter and postoperative recovery was faster and propofol requirements for induction and maintenance of anaesthesia were significantly lower with dexmedetomidine (p<0.05, p<0.01). Mean arterial pressure in Group D decreased significantly only after premedication. Heart rate values in group D were significantly lower after premedication, after intubation, after incision, at 20th min. and 60th min. of the operation. Dexmedetomidine causes bradycardia and hypotension but it can be used as iv premedication agent with careful management.