Akademik Veri Yönetim Sistemi
4th INTERNATIONAL CONFERENCE ON HEALTH, ENGINEERING AND APPLIED SCIENCES, Paris, Fransa, 12 - 14 Nisan 2024, ss.180-181, (Özet Bildiri)
The immune system is responsible for
protecting and defending our body under normal conditions and helps living
things survive by neutralizing factors such as pathogens and infections that
threaten the body. However, for some reasons, the body perceives itself as a
threat and attacks itself, creating defects. The diseases that occur as a
result of this situation are called autoimmune diseases, and if not intervened,
they can lead the person from disability to death. Although the underlying causes are not fully
understood, an autoimmune disease may also predispose to the formation of
another autoimmune disease. However, as a result of research, it is thought
that environmental factors together with genetic factors form a whole and cause
these diseases. On the other hand, sometimes consumed foods or nutritional
components may cause undesirable consequences for individuals. For example,
studies have shown that the development of Hashimoto's thyroiditis (HT), an
autoimmune disease, is supported by a gluten-containing diet. 70-80% genetic
factors and 20-30% environmental factors play a role in the progression of this
disease. While HT cases have increased rapidly in the last 30 years, the
prevalence of the disease increases with age. HT, also known as chronic
lymphocytic thyroiditis, is one of the most common autoimmune disorders of the
thyroid gland. In the pathogenesis of the disease, there is a close connection
with autoantibodies with lymphocytic infiltration along with B and T cells in
the thyroid tissue. Chronic fatigue, irritability, unstable mood, as well as
stomach, intestinal or cardiovascular problems may be observed in these
patients. Additionally, a link has been identified between increased HT and
primary thyroid lymphoma and papillary thyroid cancer. Although reported
studies suggest that gluten exclusion may be beneficial for some individuals
with HT, the diet is very limited, difficult to follow, and carries the risk of
nutritional deficiency. In this review, the effect of gluten, a protein found
in grains, on some common autoimmune diseases such as Hashimoto's thyroiditis
has been examined in the light of current scientific publications. Answers were
sought to the questions of whether removing gluten from the diet of individuals
with autoimmune diseases would benefit the individual or alleviate their
clinical symptoms.
Keywords: Hashimoto's
thyroiditis, Gluten-free diet, Autoimmune diseases, Immune system