Neuroprotective effects of hemicraniectomy in malignant middle cerebral artery infarctions: experimental study


Altintas O., Antar V., Baran O., Karatas E., Altintas M. O. , Kesgin S., ...Daha Fazla

JOURNAL OF NEUROSURGICAL SCIENCES, cilt.63, sa.6, ss.714-722, 2019 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 63 Konu: 6
  • Basım Tarihi: 2019
  • Doi Numarası: 10.23736/s0390-5616.16.03444-5
  • Dergi Adı: JOURNAL OF NEUROSURGICAL SCIENCES
  • Sayfa Sayıları: ss.714-722

Özet

BACKGROUND: Despite optimal medical therapy the mortality rate approaches 50% in MCA infarctions. Although recent studies have been showed life-saving effect of hemicraniectomy; there are a few data available in regard to neuroprotection effect of decompressive craniectomy (DC). We induced a malignant cerebral ischemia model by intraluminal permanent middle cerebral artery occlusion (MCAo) in male rats for defining the neuroprotective effects of early DC on brain-blood barrier (BBB) molecular changes, infarct size and cerebral edema.