Neuroprotective effects of hemicraniectomy in malignant middle cerebral artery infarctions: experimental study


Altintas O., Antar V., Baran O., Karatas E., Altintas M. O. , Kesgin S., ...More

JOURNAL OF NEUROSURGICAL SCIENCES, vol.63, no.6, pp.714-722, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 63 Issue: 6
  • Publication Date: 2019
  • Doi Number: 10.23736/s0390-5616.16.03444-5
  • Title of Journal : JOURNAL OF NEUROSURGICAL SCIENCES
  • Page Numbers: pp.714-722

Abstract

BACKGROUND: Despite optimal medical therapy the mortality rate approaches 50% in MCA infarctions. Although recent studies have been showed life-saving effect of hemicraniectomy; there are a few data available in regard to neuroprotection effect of decompressive craniectomy (DC). We induced a malignant cerebral ischemia model by intraluminal permanent middle cerebral artery occlusion (MCAo) in male rats for defining the neuroprotective effects of early DC on brain-blood barrier (BBB) molecular changes, infarct size and cerebral edema.