Neuroprotective effects of hemicraniectomy in malignant middle cerebral artery infarctions: experimental study

Altintas O., Antar V., Baran O., Karatas E., Altintas M. O., Kesgin S., ...More

JOURNAL OF NEUROSURGICAL SCIENCES, vol.63, no.6, pp.714-722, 2019 (SCI-Expanded) identifier identifier identifier


BACKGROUND: Despite optimal medical therapy the mortality rate approaches 50% in MCA infarctions. Although recent studies have been showed life-saving effect of hemicraniectomy; there are a few data available in regard to neuroprotection effect of decompressive craniectomy (DC). We induced a malignant cerebral ischemia model by intraluminal permanent middle cerebral artery occlusion (MCAo) in male rats for defining the neuroprotective effects of early DC on brain-blood barrier (BBB) molecular changes, infarct size and cerebral edema.