Leiomyosarcoma of the breast: Differential diagnosis

Ciralik H., Ezberci F., Buelbueloglu E., Citil R.

TURKIYE KLINIKLERI TIP BILIMLERI DERGISI, vol.27, no.2, pp.298-300, 2007 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 2
  • Publication Date: 2007
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.298-300
  • Keywords: breast, breast neoplasms, leiomyosarcoma
  • Bezmialem Vakıf University Affiliated: No


Sarcomas of the breast account for less than 1% of breast tumors. Leiomyosarcoma is an extremely rare form of primary breast sarcoma. We presented here a case of primary leiomyosarcoma of the breast in a 66-year-old woman. The mastectomy specimen contained a lobulated mass. Microscopically, the two tumors showed diffuse proliferation of spindle cells with oval and blunt-ended nuclei arranged in short fascicles or bundles. There was moderate-prominent cytological atypia, necrosis and 10 and 12 mitotic figures per 10 high power fields. The tumor cells were strongly immunoreactive for markers of smooth-muscle differentiation, including desmin and actin, and negative for other markers. We reviewed the clinical presentation, diagnosis, therapy, and pathologic features, since the tumor is uncommon and very important in the differential diagnosis.