INVESTIGATION OF THE EFFECT OF CURCUMIN ON CYTOTOXICITY, GENOTOXICITY, AND APOPTOSIS ON BREAST CANCER CELLS

Bozali K., Guler E. M., Celikten M.

WORLD CANCER RESEARCH JOURNAL, vol.9, pp.1-8, 2022 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 9
  • Publication Date: 2022
  • Doi Number: 10.32113/wcrj_20221_2149
  • Journal Name: WORLD CANCER RESEARCH JOURNAL
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus
  • Page Numbers: pp.1-8
  • Keywords: Apoptosis, Breast cancer, Curcumin, Cytotoxicity, Genotoxicity, DNA-DAMAGE, IN-VITRO, CHEMOPREVENTION, GENERATION
  • Bezmialem Vakıf University Affiliated: Yes

Abstract

Objective: In many preclinical studies, curcumin has been anticarcinogenic in several cancer types. In line with these findings, this research aims to investigate the effects of curcumin on cytotoxicity, mitochondrial membrane potential (MMP), glutathione (GSH), intracellular reactive oxygen species generation (iROS), apoptosis, and DNA damage in breast cancer cell lines.