INVESTIGATION OF THE EFFECT OF CURCUMIN ON CYTOTOXICITY, GENOTOXICITY, AND APOPTOSIS ON BREAST CANCER CELLS

Bozali K., Guler E. M., Celikten M.

WORLD CANCER RESEARCH JOURNAL, cilt.9, ss.1-8, 2022 (ESCI, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 9
  • Basım Tarihi: 2022
  • Doi Numarası: 10.32113/wcrj_20221_2149
  • Dergi Adı: WORLD CANCER RESEARCH JOURNAL
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
  • Sayfa Sayıları: ss.1-8
  • Anahtar Kelimeler: Apoptosis, Breast cancer, Curcumin, Cytotoxicity, Genotoxicity, DNA-DAMAGE, IN-VITRO, CHEMOPREVENTION, GENERATION
  • Bezmiâlem Vakıf Üniversitesi Adresli: Evet

Özet

Objective: In many preclinical studies, curcumin has been anticarcinogenic in several cancer types. In line with these findings, this research aims to investigate the effects of curcumin on cytotoxicity, mitochondrial membrane potential (MMP), glutathione (GSH), intracellular reactive oxygen species generation (iROS), apoptosis, and DNA damage in breast cancer cell lines.