Fructose-coated nanoparticles: a promising drug nanocarrier for triple-negative breast cancer therapy

ZHAO J., BABIUCH K., Lu H., Dag A., GOTTSCHALDT M., STENZEL M. H.

CHEMICAL COMMUNICATIONS, cilt.50, sa.100, ss.15928-15931, 2014 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 50 Sayı: 100
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1039/c4cc06651k
  • Dergi Adı: CHEMICAL COMMUNICATIONS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.15928-15931
  • Bezmiâlem Vakıf Üniversitesi Adresli: Evet

Özet

Fructose transporter GLUT5 is overexpressed in breast cancer cell lines, but not in healthy tissue. Micelles based on fructose, which were found to be low fouling, showed a high uptake by breast cancer cells (MCF-7 and MDA-MB-231 cells), but only negligible uptake by macrophages.