Fructose-coated nanoparticles: a promising drug nanocarrier for triple-negative breast cancer therapy

ZHAO J., BABIUCH K., Lu H., Dag A., GOTTSCHALDT M., STENZEL M. H.

CHEMICAL COMMUNICATIONS, vol.50, no.100, pp.15928-15931, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 50 Issue: 100
  • Publication Date: 2014
  • Doi Number: 10.1039/c4cc06651k
  • Journal Name: CHEMICAL COMMUNICATIONS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.15928-15931
  • Bezmialem Vakıf University Affiliated: Yes

Abstract

Fructose transporter GLUT5 is overexpressed in breast cancer cell lines, but not in healthy tissue. Micelles based on fructose, which were found to be low fouling, showed a high uptake by breast cancer cells (MCF-7 and MDA-MB-231 cells), but only negligible uptake by macrophages.