A new clerodane diterpene and other constituents from Ajuga chamaepitys ssp laevigata


Topcu G. , KOKDIL G., TURKMEN Z., VOELTER W., ADOU E., KINGSTON D.

ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES, vol.59, no.5, pp.584-588, 2004 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 59 Issue: 5
  • Publication Date: 2004
  • Title of Journal : ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES
  • Page Numbers: pp.584-588
  • Keywords: Ajuga chamepitys ssp laevigata, terpenoids, biological activity, TEUCRIUM, PLANTS

Abstract

From Ajuga chamepitys ssp. laevigata, a new clerodane diterpene, ajugalaevigatic acid, has been isolated besides five known compounds, a diterpene, (13S)-15-hydroxylabd-8(17)-en-19-oic acid, a steroidal glucoside, 3-O-beta-D-glucopyranosyl-stigmasta-5,25-diene, and triterpenes, alpha- and beta-amyrin and ursolic acid. Their structural elucidation is based on NMR and MS spectroscopic analyses. For the new compound 2D NMR experiments were carried out. Ajugalaevigatic acid was tested against a panel of cytotoxic cell lines, and only found to be active against the A2780 human ovarian cancer cell line.