Can Visual Hallucinations be among the Neuropsychological Manifestations of Systemic Mastocytosis?: A Geriatric Case

Kilic Ö. , Yilmaz U. E. , Komesli Z., Ercan A. C. , Cetiner M.

PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY, vol.30, no.3, pp.123-125, 2020 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 3
  • Publication Date: 2020
  • Doi Number: 10.5455/pcp.20200316094036
  • Page Numbers: pp.123-125


Mast cells are considered sensors of environmental and emotional stress, exist in all body parts and are related to the pathway from stress to inflammation. Mastocytosis defines a rare disease characterized by the accumulation of abnormal mast cells in multiple organs. Here, we present a 77-year-old woman with a background of aggressive systemic mastocytosis who developed impaired cognition, depression, anxiety, visual hallucinations, delusions, and insomnia. Symptoms alleviated only after initiating midostaurin, a tyrosine kinase inhibitor. Systemic mastocytosis should be kept in mind when visual hallucinations are concomitant with chronic or recurrent multi-system disturbances and do not benefit from treatment as usual.